Therapeutic composition



Patented Aug. 15, 1944 THERAPEUTIC comosrrron Charles 0. JohnsomNewYork, N. Y., assignor to Inc., New York, N. -Y., a

Latimer Laboratory,

York

No Drawing. Application February 3, 1942,

I corporation of New Serial No.

1 Claim.

The present invention is concerned with compositions of the type thatfunction by the release of nascent oxygen under body heat .for sustainedtherapeutic action.

As conducive to a clear understanding of the invention, it is noted thatwhile the maximum available oxygen content of ozonized olive oillorpractical purposes, is but 1.3 per cent, yet it is not feasible to usethat composition full strength on delicate tissues. Such compositionwill cause a severe and painful stinging sensation when applied to thenasal passages for instance,

unless the oxygen content is maintained at or below .5 per cent, 1. e.,not more than one-third full strength. Moreover, the completely ozonizedolive oil has objectionable'odors that are not easy to mask, and theattempt to mask the s to other difficulties. v

Such ozonized oilis furthermore relatively immiscible with other oilssuch as unozonized olive oil or mineral oil, so that dilution of 'fullstrength ozonized oil gives rise to mechanical difficulties, aside fromthe reduced therapeutic eiiectiveness of the diluted product. eignmaterial such as solubilizing agents, in an efiort to promote themixture of the ozoniz-ed oil .with diluent is apt to lead to othercomplications,

n the. other hand, where it is attempted to ozonize the olive oil to alesser degree, within the V limits that admit of painless application todelicate tissues the critical control of such limited e leads Theintroduction of forembodiment, substantially pure glycerinetrioleate isozonized by any of the conventional ozonizing processes, desirably bys'lent electric discharge. The double bondofeach of the three acidradicals which esterify the glycerol is thus ozonized,

three oxygen atoms bridging between the carbon atoms that flankthedouble bond on each of the three acid radicals.

The compound, when ozonized to the maximum extent practically attainableon a commercial scale, may. contain as high as 1.85 per cent ofavailable oxygen thus added to the molecule of glycerol trioleate, andthis is fully nity per cent higher than the corresponding maximum 1. e.'1. per cent of oxygen capable of being combined with olive oil. I Theefiectiveness of the composition is thus considerably greater than thatof ozonized olive oil,

. as those of the nasal passages even when used sues to which it isapplied, without r .addition of oxygen to the molecule-is dimcult andthe stability of the product on storage is relatively low.

It is among the objects of the present invention to provide acomposition with an oxygen content capable of being slowly released innascent vform under body heat, which oxygen content shall be much higherthan the maximum attainable with olive oil, and which-composition shallyet be non-irritating in its full concentration.

even'when applied to the most'delicate tissues of the human body such,for instance, as the nasal passages.

Another object is to provide a composition for the above purpose,.whichis suiilciently viscous to stay in place for effective action on theorgan or upon the-tissue to. which it is applied, which has noobjectionableodor, and which; while it efiectively releasesnascentoxygen when applied to body tissues, will retain its effectiveness ror'all practical purposes, when sealed'in a jar or flask in storage atnormal "room temperature for a period as much astwo years.

0 the ozonized glycerol trioleate even with its high apart from thevitally important. circumstance that it is non-irritating to delicatetissues such By reason of its high added oxygen ingly 'ozonizedolive'oil, sothat it will more reliably' remain in situ on the organ oron the tiseadily flowing therefrom and will function for hours by the aslow release of therapeutic nascent oxygen given up bythe molecule underbody heat. The composition has no objectionable odor and need thereforenot be masked and the mechanical diflicul'ty of admixing essential oilstherewith and the dilution-and other objections incurred by such maskingare obviated.

Except for the desiredrelease of nascent oxygen there is no break-downof the molecular structure of the composition during use. No foreignmatter such as ketones, aldehydes or thelike, even small proportions ofwhich would be irritating is present or is formedin the course of theuseof thecomposition.

While the pr ce 0! such stable saturated oils in the composition as maybe-miscible with the ozonized glycerlne trioleate would theoretionly dono particular harm hysiologically, lution would be incurred, .so thatthe available nascent oxygen is of-lowe ercentage andthe composition isaccordingly less eflective, without advantages, since as above noted,

' av ble nascent oxygen content is non-irritating to delicate tissu sThe relatively viscous composition constituting According totheinventiomin one. practical the medicament or the present inventionwill not deteriorate materially when stored in flas or jars at norma1room temperatures.

The composition is germicidal, fungicidal and nasal and vaginal tracts,the sinuses and the like. The composition produces exceptionallymeritorious results in the treatment of secondary or tertiary burns.Another application is as a vermifuge. The composition may be solidifiedsuftory purposes, by admixing the samewith hydrogenated cotton seed oilor the like.

Esters of fatty acids with two double bonds,

tionable from this standpoint. The ozonization of oils that contain suchingredients even in small proportions, especially if they also containoxidizable coloring and flavoring matter is not some of them tend toexplode on ozonizing.

As many changes could be made in the above out. polymerization,oxidation or decomposition.

CHARLES C. JOHNSON.

